FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF COLCHICINE
AbstractThis study aimed to develop and assess a fast-dissolving oral film (FDOF) for colchicine, targeting enhanced patient compliance and rapid therapeutic onset, particularly for acute gout management. Colchicine, a powerful anti-inflammatory medication, often faces patient adherence challenges due to gastrointestinal side effects and delayed onset in conventional oral forms. FDOFs offer a compelling alternative by dissolving rapidly in the oral cavity without water, improving drug bioavailability and reducing gastrointestinal irritation. The films were formulated using suitable polymers, plasticizers, and super disintegrants through a solvent casting method. Key evaluation parameters included film thickness, folding endurance, disintegration time, drug content uniformity, and in-vitro drug release. Results indicated that the optimized films demonstrated rapid disintegration, excellent mechanical strength, and efficient drug release, making this delivery system a promising alternative for colchicine therapy.
Article Information
21
3120-3124
576 KB
9
English
IJPSR
Vaishnavi Mahadik *, Suyash Yevale and Shubham Chavan
Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India.
mahadikvaishnavi033@gmail.com
23 May 2025
22 June 2025
28 June 2025
10.13040/IJPSR.0975-8232.16(11).3120-24
01 November 2025
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