FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE
AbstractOndansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Dissolvable dissipation techniques were utilized for such readiness. Totally taste veiling with zero arrival of medication in phosphate support pH 6.8 was acquired from granules arranged by dissolvable vanishing strategy utilizing drug: polymer proportion of 1:2, from which four equations pass a pre-pressure assessment and compacted to FDTs and assessed for their medication content, in-vitro breaking downtime, in-vivo deterioration time, wetting time and in-vitro drug discharge profile. It was tracked down that the tablet definitions F8 with cross carmellose sodium as super disintegrant showed the fast medication discharge when contrasted with unadulterated medication. T50 and DE 30% for the definition F8 was discovered to be in 7 min and 73.5%, Hence reasonable as quick-dissolving tablets.
Article Information
18
1598-1607
948 KB
1192
English
IJPSR
K. Muni Raja Lakshmi * and G. Asuntha
Department of Pharmaceutics, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
munirajalakshmi005@gmail.com
27 September 2021
20 January 2022
21 March 2022
10.13040/IJPSR.0975-8232.13(4).1598-07
01 April 2022