FORMULATION AND EVALUATION OF FLOATING GEL BEADS OF LORATADINE
AbstractA floating controlled drug delivery system of loratadine was formulated to enhance the retention time in the stomach and to modify the release characteristics of loratadine. Loratadine loaded floating gel beads were prepared by ionic gelation technique using different polymers such as HPMC K4M, HPMC K15M, and carbopol 934P in different proportions and sodium bicarbonate as the gas forming agent. FT-IR spectra revealed that there was no significant interaction of loratadine with the carriers and other excipients. The prepared beads were evaluated for particle size analysis, bulk density, tapped density, compressibility index, hausner’s ratio, the angle of repose, swelling index, drug entrapment efficiency, % yield, % buoyancy of loratadine floating beads, in-vitro drug release studies, kinetic modeling of drug release and stability studies. Results of the in-vitro drug release study indicated sustained release of loratadine for up to 12 h. The drug release kinetics of optimized formulation F7 was best fitted with the zero order and Peppas model with n>0.45.
Article Information
39
1289-1299
1,140
1194
English
IJPSR
S. A. Begum *, J. Jhansi and K. Padmalatha
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India.
arifashaik2007@gmail.com
26 June 2018
28 September 2018
05 October 2018
10.13040/IJPSR.0975-8232.10(3).1289-99
01 March 2019
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