FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF METFORMIN HCl FOR THE TREATMENT OF TYPE-2 DIABETES MELLITUS
AbstractFloating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. Independent variables were total amount of hydrophilic gel forming polymers (Hydroxyl Propyl Methyl Cellulose K15M and Carbopol 934P) X1 and polymer-polymer ratio X2. The prepared formulations were evaluated for various physicochemical, buoyant and in-vitro drug release characteristics. All formulations possessed good floating properties with total floating time more than 12 hours. Statistical Optimization carried out for various responses like ‘n’ of Peppas equation, ‘K’ of zero order and ‘n’ of higuchi equation and T80%. Optimized formulation was found to float for longer duration and provided more sustained release of the drug. Release kinetics of optimized formulation followed Higuchi model with anomalous non -fickian diffusion. Hence Optimized floating matrix tablet could be a promising delivery system for Metformin hydrochloride with sustained release action and improved drug availability.
Article Information
28
3065-3072
826KB
1328
English
IJPSR
Ishab Kumar*,Gali Vidyasagar , Anil Bhandari and Nishant Upadhyay
Department of Pharmaceutical Sciences, Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur, Rajasthan, India
Department of Pharmaceutical Sciences, Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur, Rajasthan, India
31 March, 2013
14 June, 2013
26 July, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(8).3065-72
01 August, 2013
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