FORMULATION AND EVALUATION OF GLIBENCLAMIDE ORAL DISPERSIBLE TABLET BY SOLID DISPERSION TECHNIQUE
AbstractGlibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-soluble carrier. The solid dispersion of Glibenclamide was prepared by using fusion methods. The characterization of Glibeclamide solid dispersion powder was done by using several parameters like bulk density, tapped density, Carr’s Index, Hausners’s ratio, drug content, solubility and in-vitro dissolution study. While the oral dispersible tablet was prepared by using direct compression method. The prepared tablets were evaluated for disintegration time, moisture content, friability, and wetting time. From this study, it can be concluded that fast disintegrating tablets could be a potential drug delivery technology for managing diabetic patients.
Article Information
38
406-415
1009 KB
487
English
IJPSR
Rakshita Chaudhari, Rahul Wagh *, June Milind Wagh and Valmik Wagh
Department of Chemistry, Patkarcollege, Goregaon (W), Mumbai, Maharashtra, India.
drrahulwagh123@gmail.com
10 May 2022
11 June 2022
24 July 2022
10.13040/IJPSR.0975-8232.14(1).406-15
01 January 2023
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