FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF VALSARTAN
AbstractThe immediate release tablet of antihypertensive drug Valsartan were prepared and evaluated to increase solubility and bioavailability of low soluble drug. The tablets were prepared by direct compression method using Surfactants such as Poloxamer 188, Sodium stearate, Sodium Lauryl Sulfate and Superdisintegrant such as Cross carmellose sodium were used in tablet formulation. The formulation were evaluated for various physical parameters, dissolution study and drug release profile. From all formulations the formulations F-C of batch B 3 i.e SLS-3 showed 98.04% drug release within 30 minutes, which was highest drug release than other batches. The optimized immediate release tablet of batch B 3i.e SLS-3 of formulation F-C showed no change in physical appearance, drug content or in dissolution pattern storage at 40± 20 C / 75 ± 5 % for 90 days. Finally it was concluded that batch B-3 containing formulation F-C i.e. SLS-3 shows highest drug release.
Article Information
42
808-815
732
3288
English
Ijpsr
Rohit S. Kulkarni*and Dr. Amulyaratna L. Behera
Vishal Institute of Pharmaceutical Education and Research, Ale Tal- Junnar, Dist-Pune, Maharashtra, India.
rohitkulkarni452@gmail.com
18 June, 2014
28 August, 2014
15 November, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.6(2).808-15
01 February, 2015
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