FORMULATION AND EVALUATION OF LEVOFLOXACIN OINTMENT

We intended desired ointment developed for bacterial infection.  So Levofloxacin is a fluoroquinolones of antibacterial drug effective in the treatment of bacterial conjunctivitis, sinus, kidney, bladder or prostate Here the main objective of the present work is besides delivering drugs to the body, A drug delivery system to improve patient compliance and dispersible are no exception.  So we have selected the topical drug delivery system by using a formulation of ointment. The Levofloxacin ointment is prepared by the two ointment bases, namely Oleaginous and Emulsion bases. To assess the efficiency of Levofloxacin ointment by physical appearance, viscosity, PH and spreadibility, Rheological properties and micro biological studies. The Oleaginous base prepared by using white bees wax and petrolatum and emulsion base having the methyl paraben, propyl paraben, sodium lauryl sulfate, propylene glycol, stearyl alcohol white, white petrolatum, purified water.  The % of drug content of Levofloxacin was found to be 99.53.  The PH was found to be 5.1 % colour was found to be formulation A (Oleaginous) is light yellowish and formulation B(Emulsion) is cream colour.  The viscosity was found to be for formulation A & B have 96600.  The spreadability was found to be formulation A: 6, B: 7. Extrudability was found to be for formulation A & B have 97.6%.  Globule diameter formulation A: 4.20 and B: 4.33. The evaluation tests, results are taken for 3 months; it gives the accurate and satisfactory results.