FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETAbstract
The objective of the present study was to develop venlafaxine hydrochloride orodispersible tablet by using conventional techniques which are simple and cost effective such as use of superdisintegrant technology. In this, sodium starch glycolate and Crosscarmellose sodium crosspovidone and kyron-T-314 were used in the rapid disintegration of the tablets. In this various trials were conducted for the selection of optimum concentration of superdisintegrant. The optimized formula aids in the stabilization of final product. The blend and compressed tablets were evaluated for physical characteristics like bulk density, tapped density, angle of repose, hardness, friability, disintegration time, wetting time, water absorption ratio, In-vitro dispersion time and chemical characteristics like In-vitro dissolution, content uniformity and assay. The stability study was conducted for the optimized batch. This design of dosage form will open a new era for rapid disintegration tablets.
Vishal Sahu* and B.V. Bakade
P. Wadhwani College of Pharmacy, Amravti University, Amravti, Maharashtra, India
19 August, 2012
15 September, 2012
25 November, 2012
01 December, 2012