FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS BY USING NATURAL POLYMERAbstract
The study was aimed at developing mucoadhesive buccal tablet containing Carvedilol. The effect of two independent variables, Casein (X1) and hydroxypropylmethyl cellulose (HPMC K4M) (X2) at three different levels (-1, 0, +1) on dependent variable including hardness (Y1), cumulative percentage drug release at 6 h (Y2) and 12 h (Y3) using 32 full factorial design. FTIR and DSC results showed no evidence of interaction between the drug and polymers. All physicochemical parameters were within permissible Pharmacopoeial limits. The concentrations of independent variables had profound effect on dependent variables. The hardness of the optimized formulation F3 was 5.43 kg/cm2, and the drug release was found to be 53.32% at the end of 6 hrs (Q6) and 95.16% at the end of 12 h (Q12). The optimized formulation followed zero-order release kinetics with non-fickian drug release mechanism. The study revealed that mucoadhesive buccal tablets could be successfully formulated using Casein and HPMC K4M using 32 full factorial design in the buccal delivery of Carvedilol. The result indicates that suitable innovative mucoadhesive buccal tablets may be prepared with desired bioavailability and mucoadhesion and it can be better option to by-pass hepatic metabolism.
A. Balaji, V. Radhika * and V. goud
Centre for Biopharmaceutics and Pharmacokinetics, Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar, Andhra Pradesh, India.
13 February 2014
04 July 2014
31 July 2014
01 November 2014