FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF CIMETIDINE FOR ITS GASTRO RETENTIVE DRUG DELIVERY EFFICACY

The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of the model drug by using polymers like Sodium alginate and Carbopol 934 as an excellent mucoadhesive agent that can adhere to the gastrointestinal membrane for sustained drug delivery in the stomach. Calcium chloride was also used for making a solvent system. The preformulation study shows no interaction between drugs and excipients. The prepared microspheres of cimetidine particle size between 167.14-218.23μm. The entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after 7 h of F6 formulation showed good release was 85.60 %. SEM of prepared microspheres reveals a very smooth surface with a spherical shape. All prepared formulations exhibit good percentage yield and drug release rate. The increased amount of polymer was raised the particle size of microspheres significantly. In-vitro drug release studies were used to indicate a controlled and prolonged release of drug in the stomach and intestine. So we can say the formulation F6was a better candidate of all the developed formulations.