FORMULATION AND EVALUATION OF NIFEDIPINE LIQUISOLID TABLET
AbstractThe liquisolid technique is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dried powder by simple physical blending with selected carrier and coating material. The in vitro dissolution property of poorly water soluble Nifedipine was improved by exploring the potential of liquisolid technique. Different liquisolid tablets were prepared by suspending Nifedipine in PEG 400 with Avicel PH 102 as carrier, Aerosil 200 as coating material and Sodium starch glycolate as disintegrating agent. The liquid load factors for liquid vehicle was calculated to obtain the optimum amounts of carrier and coating materials necessary to produce acceptable flowing and compactable powder admixtures viable to produce tablets. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability and drug content uniformity. The interaction between drug and excipients in prepared Liquisolid tablets were studied by differential scanning calorimetry (DSC) and FT-IR. The result showed that liquisolid formulation of Nifedipine exhibited higher percentage of drug release than directly compressed tablets which show significant benefit of liquisolid tablet in increasing wetting properties and surface area of drug available for dissolution. From this study it concludes that the liquisolid technique is a promising alternative for improvement of dissolution property of poorly water soluble drugs.
Article Information
39
588-595
575KB
1546
English
IJPSR
Jayshri Y. Chaudhari*, Bharat W. Tekade, Vinod M. Thakre and Vijay R. Patil
Department of Pharmaceutics, TVES’s Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Tal- Yawal, Dist- Jalgaon, Maharashtra, India
chaudhari.jayshri90@gmail.com
28 September, 2013
18 November, 2013
14 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).588-95
01 February, 2014