FORMULATION AND EVALUATION OF NUTRACEUTICAL DRY POWDER SUSPENSION USING MORINGA OLEIFERA LEAVES AND CELASTRUS PANICULATUS SEEDS EXTRACTS

Herbs, which have been used to cure numerous ailments since ancient times, play an important role in building the foundation of modern medications. The present study aimed to investigate the antioxidant potential of nutraceutical dry powder suspension formulated with Moringa oleifera leaves and Celastrus paniculatus seeds extract against DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate). Plant extracts are prepared using ethanol as a solvent in the Soxhlet apparatus and extracts are evaluated for antioxidant activity using ascorbic acid as standard and best % inhibition of free radicals the dose is selected for formulation. Further evaluation studies are carried out for all the batches to finalize the optimized batch showing good flow properties and drug release profile. Both plant extracts showed good % Radical scavenging activity (%RSA) compared to ascorbic acid’s scavenging activity. The optimized formulation showed acceptable evaluation results, including pH, angle of repose, carr’s index, hausner ratio, sedimentation volume, redispersibility, viscosity and drug release. The formulated dry powder suspension formulation showed good antioxidant activity. Thus, the present investigation revealed that the developed nutraceutical antioxidant formulation is formulated and all evaluation criteria are within the limit.