FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF CINNARIZINE USING DIRECT COMPRESSION TECHNIQUE
AbstractIn the present work, oral dispersible tablets of cinnarizine were prepared by direct compression method with a view to enhance patient’s compliance. Five different superdisintegrants viz. crosspovidone, sodium starch glycolate, crosscarmellose sodium and low-substituted hydroxypropylcellulose (L-HPC) and pregelatinized starch were used along with microcrystalline cellulose (Avicel PH 102) and directly compressible mannitol (pearlitol SD-200) which enhances the mouth feel. Fifteen formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and in vitro disintegration time. Among the formulations tablets of batch F9 containing crosspovidone (at 4.5% level) showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compared to other formulations. It was concluded that superdisintegrants addition technique is a useful method for preparing oral dispersible tablets by direct compression method.
Article Information
31
961-967
577
1795
English
Ijpsr
Nitesh J. Patel*, C. S. R. Lakshmi, Hitesh P. Patel and Sagar Akul
Department of Pharmaceutics, Nargund College of Pharmacy, Bangalore, Karnataka, India
29 December, 2010
10 February, 2011
14 March, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(4).961-67
01 April, 2011
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