FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF OFLOXACIN BY USING DIFFERENT NATURAL SUPER DISINTEGRATING AGENTS

Fast disintegrating tablets have received ever-increasing demand during the last decade, particularly the fast disintegrating tablet drug delivery systems formulated with natural polymers have more demand because natural materials are easily available, easy to administer, non-toxic and non-irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablet of Ofloxacin using Hibiscus leaves and Okra fruit dried mucilage. The results obtained from the natural polymer were compared with the synthetic super disintegrants sodium starch glycolate. Ofloxacin in an antibacterial drug used to treat various infections and having bitter taste. Its bitter taste is first masked by entrapping it into microspheres using Eudragit RL 100 polymer. The microspheres were evaluated for particle size, entrapment efficiency, in-vitro release and bitterness threshold. The selected microspheres were directly compressed into the tablets. The orodispersible tablets using different super disintegrants with varying concentrations were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, drug content, disintegration time and drug release. FTIR and DSC study of drug and polymer were done to check drug-polymer interaction. The orodispersible tablet made from natural disintegrants was found superior over an orodispersible tablet made from a synthetic polymer.