FORMULATION AND EVALUATION OF PERIODONTAL FILMS CONTAINING LEAF EXTRACT OF PSIDIUM GUAJAVA FOR TREATING PERIODONTITIS

The aim of this study was to investigate the antibacterial activity of Psidium guajava leaf extract in periodontal film for inserting in periodontal pockets. The study was performed by formulating bioerodible periodontal film containing Psidium guajava leaf extract by simple solvent casting method using two different polymers namely natural chitosan and semi synthetic HPMC. The formulated periodontal films were then cross linked with 2 % v/v glutaraldehyde for 3 hours for extending the release of drug. The periodontal films were evaluated for various physico-chemical parameters. The cumulative percentage drug release was found to be higher for periodontal film prepared with chitosan polymer. The results from the in-vitro release studies of Psidium guajava leaf extract from different batches of periodontal film have shown that the release followed zero order release kinetics for the batch F₄. The results of release data for batch F₄ fits well in Higuchi model, suggesting diffusion mechanism of drug release. The research findings have concluded that both chitosan and HPMC could be used for preparing periodontal film for extending the release of drugs.