FORMULATION AND EVALUATION OF POLY-HERBAL ANTI-ACNE FACEWASH

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects the major oil gland-containing areas, such as the face, back, and trunk. It involves increased sebum production and hair follicles abnormally desquamate as a result of rising androgen levels that coincide with puberty. It is generally characterized by, the formation of seborrhea, comedones, inflammatory papules, pastures, nodules, and lesions. Propionibacterium acnes and Staphylococcus epidermidis have been identified as bacteria that cause acne inflammation by generating pus. Staphylococcus aureus contributes to causing inflammation in acne. Herbal formulations have growing demand in the world market So, the current research focuses on developing and assessing a herbal face wash against the acne vulgaris and its etiologic agent. The ethanolic extract of Turmeric (rhizomes), Neem (leaves), Black pepper (fruit) and Nutmeg (fruit) was prepared by using a maceration process and formulated into a topical gel. The plants have been used in the formulation the having good anti-microbial, anti-oxidant and anti-inflammatory activity. The gel was formulated with different concentrations of the extract by dispersion method and the prepared formulation has been evaluated for a number of parameters like odor, color, appearance, consistency, pH, spreadability, wash ability, skin irritancy, and antimicrobial activity. The agar well diffusion method was used to test in-vitro antibacterial activity against P. acnes, S. epidermidis, and S. aureus. The produced formulation’s-zones of inhibition were compared with a conventional antibiotic (Clindamycin) or herbal formulation.