FORMULATION AND EVALUATION OF PROGRAMMED RELEASE OCULAR INSERTS OF MIZOLASTINE
AbstractThe main objective of this study was to prepare controlled release matrix type ocular inserts of mizolastine for the treatment of seasonal allergic conjunctivitis.The films were prepared by solvent casting technique using Eudragit RL100 and RS100 in different ratios with dibutylphthalate as the plasticizer. The films were evaluated for the physicochemical parameters. In-vitro studies were carried out using Franz-diffusion cell (bi-chamber compartment model)and ex-vivo studies of the optimized formulation were carried out using goat’s cornea. In vivo studies were performed using rabbit as the animal model. Formulations F4andF6, which showed controlled and prolonged in vitro drug release, were subjected to in vivo study. In vitro and in vivo correlation was found to be good, revealing the efficacy of the formulations.Formulation F6 was found to be promising, as it achieved the objective of the present study.
Article Information
67
497-501
643KB
1174
English
IJPSR
Hema Bansal, Sadhna Khatry* and Sandeep Arora
Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Punjab, India
sadhna.khatry@chitkara.edu.in
07 September, 2012
15 October, 2012
22 December, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).497-01
01 January, 2013
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