FORMULATION AND EVALUATION OF RAPIDLY ORO-DISPERSIBLE TABLET CONTAINING VENLAFAXINE HYDROCHLORIDE FOR THE TREATMENT OF ANXIETY

Purpose: The main purpose was to develop Oro-dispersible tablet to overcome the problem of dysphagia which is common in pediatric, geriatric and unconscious patients. Method: The Oro-dispersible tablets were prepared by direct compression method by using two different individual superdisintegrant like Sodium Starch Glycolate and Crospovidone as well as combination of superdisintegrant with newly marketed filler-binder Isomalt were used. Friability, disintegration time and percent drug release were taken as dependent variable. The excipients were used like Avicel as directly compressible excipient, Talc and Magnesium Stearate as lubricant, Sodium Saccharine and Mannitol as sweetening agent. The tablets were evaluated for hardness, friability, thickness, weight variation, wetting time, water absorption ratio, disintegration time and in-vitro drug release study. Venlafaxine hydrochloride, commonly used as anti-hypertensive and has anxiolytic property, poor bioavailability due to extensive first pass metabolism. Results: It was observed that hardness of all tablets was 3.13-4.11 Kg/cm², friability of all formulation was found to be less than 1%, Weight variation was as per the USP specification and maximum % drug release of optimized batch containing super disintegrating agent Sodium Starch Glycolate was 87.71% in 60 min. Conclusion: it was concluded that developed Oro-dispersible tablet of Venlafaxine hydrochloride by using superdisintegrant dissolves rapidly in mouth also drawn a comparative study between the effect of the used excipients on pharmacokinetic parameters like in-vitro drug release and bioavailability.