FORMULATION AND EVALUATION OF SAGO STARCH FILM CONTAINING LEVOCETIRIZINE DIHYDROCHLORIDE
AbstractLevocetirizine dihydrochloride is an orally active, third-generation non-sedative antihistamine used in the symptomatic relief of seasonal and perennial allergic rhinitis. It competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. The present work aimed to prepare mucoadhesive buccal films to deliver the drug in a controlled manner with a longer duration of action, which is beneficial in managing severe conditions of allergies. The semisolid casting method was used to prepare the film using different conc. of sago starch and glycerol (plasticizer) with a variation of heating time and heating temperature. The study clearly indicated the influence of heating time and concentration of sago starch on drug release profile. It was noticed that the rate of drug release increased with increased heating time and slowed as the concentration of polymer increased. Prepared mucoadhesive films were evaluated for parameters such as thickness, surface pH, swelling properties, tensile strength, drug content etc.
Article Information
46
1082-1091
824
724
English
IJPSR
D. Pathak, S. Pahwa * and S. Singh
Lloyd Institute of Management and Technology (Pharm), Greater Noida, Uttar Pradesh, India.
shilpapahwa@yahoo.co.in
12 February 2020
13 May 2020
22 May 2020
10.13040/IJPSR.0975-8232.12(2).1082-91
01 February 2021
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