FORMULATION AND EVALUATION OF SOLID DISPERSION TABLET CONTAINING TINIDAZOLE

This study focused on the development and evaluation of solid dispersions of Tinidazole, aimed at creating a fast-release tablet formulation. The preparation involved using carriers such as PEG 4000 and HPMC. Solid dispersions were created using both solvent evaporation and fusion methods. The resulting solid dispersions exhibited desirable properties, appearing as fine and free-flowing powders. Interaction studies, including IR spectra analysis, revealed no significant interaction between the drug and the carriers employed. Furthermore, uniform drug content was observed across all prepared solid dispersions. Correlation studies between the percentage of carriers in the dispersions and the dissolution behavior of pure Tinidazole indicated a positive relationship. Dissolution kinetics analysis demonstrated that the release of Tinidazole from all dispersions adhered to first-order kinetics. Notably, PEG 4000 emerged as the most effective carrier, yielding the fastest dissolution rate. The sequence of dissolution rates from various solid dispersions was determined. To extend the evaluation, Tinidazole solid dispersions in a 1:2 drug-to-carrier ratio with PEG 4000 were formulated into capsules. These capsules exhibited significantly enhanced dissolution characteristics compared to the pure drug formulation. The solid dispersion containing a 1:2 ratio of drug to PEG 4000 was identified as a fast-release dosage form of Tinidazole, surpassing the dissolution performance of both the pure drug and other ratios of Tinidazole solid dispersions. Moreover, the successful formulation and evaluation of solid dispersion tablets were achieved, representing a promising advancement in the development of a fast-release tablet formulation for Tinidazole.