FORMULATION AND EVALUATION OF STAVUDINE ORAL DISINTEGRATION TABLETS
AbstractStavudine an anti-retroviral drug is used for treating HIV now-a-days. The present approach aims to formulate an orally disintegrating tablet of stavudine for better patient compliance and bypassing the hepatic metabolism. In order to have an orally disintegrating tablet of stavudine, there is a need to mask the bitter taste. For the masking of bitter taste mannitol is used as taste masking agent. In the formulation of ODTs, a semi-synthetic super disintegrant sodium starch glycolate and a natural disintegrant, sodium alginate was used. Formulations F1, F2, F3, S1, S2 and S3 were evaluated for the required quality control tests.F3 and S3 were found to have a disintegration time of 7secs and 6secs, respectively. Upon observing the dissolution profiles and disintegration time of formulations, F3 and S3 showed good results.
Article Information
72
4036-4039
576KB
1208
English
Ijpsr
K. Lavanya Latha Reddy , T. Sowjanya, V. Sankar , G. Naga Sowjanya , R.B. Desireddy
Nalanda Institute of Pharmaceutical Sciences 1, Siddharth Nagar, Kantepudi, Sattenpalli, Andhra Pradesh, India
thotasowji07@gmail.com
21 June, 2012
23 July, 2012
28 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).4036-39
01 October, 2012
Download