FORMULATION AND EVALUATION OF STAVUDINEAS MUCOADHESIVE VAGINAL TABLETS

Mucoadhesive drug delivery system has occupied an important place in the field of pharmaceutical research. Mucoadhesive tablets prolong the residence time of the drug at the site of application and provide extended therapeutic effect. Mucoadhesive tablets have been prepared for various sites thus offering localization as swell as systemic control of drug release. The present review focuses on concept of formulation of Stavudine as mucoadhesive vaginal tablets, their applications and various evaluation techniques. A new strategy preferably once daily is proposed for improving the sustained release of drug and localized action of stavudine, the antiretroviral. The design of the delivery system was based on the sustained release formulation with swelling and mucoadhesion of the drug delivery systems. Different polymers, such as, HPMCK100M, HPMCK15M, CARBOPOL934P and binders were used with different concentrations were tried in order to get the desired sustained release profile over a period of 8-10hrs. All the formulations were evaluated for, dimensional stability, drug content and in vitro drug release profile. It was found that dimensional stability and controlled release rate of the formulation increases with the increasing polymer concentration. Based on the in vitro studies carried out for the optimized formulation the performance of the developed formulation promises to be efficient in controlling the drug release rate throughout10hrs with the HPMCK 100M and HPMCK 15M.