FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET OF TRAZODONE HYDROCHLORIDEAbstract
The main objective of this study was to formulate a Sustained release tablet by wet granulation method. A sustained release tablet of trazadone hydrochloride was prepared by using synthetic polymer. The prepared tablets were evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of the tablet range from 5.43±0.288 to 5.76±0.05 and 09.68±0.577 to 10.04±0.04, respectively. Drug content was studied, and its ranges from 92.03 to 98.60%. Hardness was studied; its ranges 5.5 to 6.5 kg/cm2, Friability ranges 0.71 to 0.95%, Weight variation ranges between 434±1.49 to 460±1.23. FTIR and DSC analysis does not show any interaction of drug with Excipient. The formulation was optimized on the basis of acceptable pre and post-compression parameters. The results of dissolution studies indicated that Batch F4 containing eudragit RL 100 exhibited drug release of 88.06% at the end of 12 h to provide sufficient concentration for achieving satisfactory therapeutic value for an extended period of time. Optimized batch best fitted to Higuchi model. The n value indicates a non-fickinan or anomalous diffusion pattern. This means that both the diffusion and erosion mechanisms were prevalent. By the above results, it can be concluded that the above-prepared tablet of trazadone hydrochloride could be able to extend the drug release by avoiding problems such as dose dumping, more gastric residence time and improve patient compliance.