FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF 18-Β-GLYCYRRHETIC ACID
AbstractAn attempt was made to formulate and evaluate the 18-β-glycyrrhetic acid (GA) transdermal drug delivery system. Preformulation studies on the drug 18-β-glycyrrhetic acid were done which included description, solubility and compatibility studies. Solvent casting technique was used to prepare the transdermal patches. Four formulations were made with 400mg of 18-β-glycyrrhetic acid and by using polymers Hydoxypropyl methylcellulose (HPMC) and Ethyl cellulose (EC) with different concentration of menthol (2%, 5%) as penetration enhancer. Interaction of drug and polymer was confirmed by FTIR studies. Transdermal patches were evaluated for the weight, thickness, percentage moisture uptake, folding endurance, water vapor transmission rate, in-vitro release and in-vivo release studies. This was done for four formulations F1, F2, F3, and F4. The F1 formulation showed a good release profile due to increase in concentration of penetration enhancer. The accelerated short term stability study indicated that the optimized formulation F1 has very good stability at 4 o / 40 o / 60 o for a period of 3 months.
Article Information
14
4581-4586
444KB
1826
English
IJPSR
Prachi Patel* and V.H. Bhaskar
Department of Pharmacognosy, M.P. Patel College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India
prach_patel@yahoo.com
13 July, 2013
13 August, 2013
17 November, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4581-86
01 December 2013
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