FORMULATION AND IN-VITRO EVALUATION OF SOLID LIPID NANOPARTICLES CONTAINING NADOLOL

The solid lipid nanoparticles are sub-micron colloidal carriers (50-100 nm) that are composed of physiological lipid dispersed in water or in aqueous surfactant solution. Nadolol-loaded SLNs were prepared by modified high shear homogenization. It was observed that all formulations contain a good product yield. The highest drug content was found in formulation F5 98.37%. Entrapment efficiency for formulation F5 (98.58 %) was maximum. F5 formulations have lowest particle size (151.76) and the lowest PDI value (0.12) good Zeta potential (-28.8). The dissolution data of Nadolol solid lipid Nanoparticles F5 formulation was shown maximum drug release at 30 min. i.e., 99.04%. Hence, F5 was concluded as an optimized formulation for solid lipid nanoparticles (Nadolol-loaded SLNs F5 formulation). The present work aimed at preparing oral film with a quick onset of action, which is very convenient for oral administration. Oral fast-dissolving films of Nadolol SLN were prepared using HPMC (E5) as film-forming polymer and PEG 400 as a plasticizer by solvent casting method. Dissolution of prepared oral films of Nadolol was performed using USP type II apparatus using pH 6.8 phosphate buffer medium at 50 rpm at temperature 37±0.5ºC temperature. The films prepared were evaluated for various parameters, which showed satisfactory results. In conclusion, the development of fast dissolving oral films using HPMC E5 300 mg polymer gives rapid drug delivery and rapid onset of action. F2 oral fast dissolving film was optimized in, which it showed a drug release of 97.36% after 30 min compared with other batch formulations.