FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASED GLIBENCLAMIDE MICROSPHERES

In the present investigation, an attempt has been made to prepare sustained release microspheres of Glibenclamide by using Eudragit RS 100 as rate retardant polymer. Microspheres were successfully prepared by non-aqueous emulsion solvent evaporation method. Magnesium stearate was used as hydrophobic dispersant and droplets stabilizer. The yields were varies from 90-97% and encapsulation efficacy is up to 94% which encourage the investigation. The desired sizes of microspheres were obtained when the stirring was carried out at 600 rpm. The in-vitro dissolution profile of optimized formulation batch i.e., F5 is resulted up 11.5 hours. The various parameters of model equation of microspheres containing Glibenclamide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi Model and Korsmeyer-Peppas Model. To establish the release kinetic, Korsmeyer-Peppas Model shows the prominent release characteristics and the release pattern is non-fickian diffusion controlled.  The SEM photograph of microspheres confirmed good spheres and smooth surface of the microspheres. The IR and DSC studies used to of confirmed the interaction between drug and polymer.