FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETSAbstract
The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was used as super disintegrants and evaluated for their flow properties, drug excipient compatibility by FT-IR, DSC, respectively. Dissolution studies for liquisolid formulation and directly compressed tablet were carried out at a buffer pH 6.8 and found an increase in drug release of 101.71% and 80.09% at 45 min, respectively.
P. R. Patil *, P. R. Mahaparale and K. U. Shaikh
Department of Pharmacy, Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India.
08 January 2020
18 May 2020
21 May 2020
01 March 2021