FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN IN COMBINATION TABLETS AND RELEASE RATE IMPROVEMENT
AbstractThe work was aimed to develop an immediate release tablet formulation of Fenofibrate and Rosuvastatin in combination for better treatment as well as management of hypercholesterolemia and prevention of cardiovascular diseases. The target was also set to improve the dissolution profile of poorly soluble Fenofibrate. For manufacturing these immediate release combined formulation tablets, Hot-Melt Technology was used which helped in enhancing dissolution profile and moreover, here amino acids are used in conjunction with other excipients. In the developed formulation, the amino acids imparted its action as excipient by helping in the solubilization process which facilitated the release rate of Fenofibrate. The formulated tables were then investigated for hardness test, friability test, weight uniformity and dissolution test. The results showed that all tablets met the expected requirements for these tests and the release rate of fenofibrate also got improved giving an excellent dissolution profile for both fenofibrate and rosuvastatin
Article Information
51
4075-79
326
1965
English
Ijpsr
Priyanka Sarkar*, Shaila Eamen, Md. Biplob Hossen and Md. Golam Mucktady
Department of Pharmacy, Primeasia University, Banani, Dhaka, Bangladesh
pyaree.dreams@gmail.com
05 March, 2015
02 June, 2015
30 June, 2015
10.13040/IJPSR.0975-8232.6(9).4075-79
01 September, 2015
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