FORMULATION DEVELOPMENT AND EVALUATION OF NANOGEL LOADED WITH MONTELUKAST SODIUM NIOSOMES

Niosomes are vesicular carriers in the drug delivery system that are reported in the seventies. They are formed by self -assembly of non –ionic surfactant and cholesterol upon hydration with aqueous media resulting in lamellar structures that encapsulates both polar and non polar drugs. In the present research work, Montelukast sodium niosomes were prepared by using non –ionic surfactant span 60 and cholesterol in 1:1 concentration by thin-film hydration method using a rotary vacuum evaporator. The prepared Montelukast sodium niosomes were incorporated into the nanogel prepared by varying concentration of carbopol 934 to check the effect of polymer concentration on gel property. Niosomal gels were optimized and evaluated for various parameters such as homogeneity, grittiness, pH, viscosity, spreadability, extrudability drug content, skin irritation, in-vitro diffusion, zeta size, zeta potential, Etem study for vesicle size and stability study. Nanogel was successfully formulated by using Montelukast sodium niosome dispersion.  The average sizes of niosome vesicles were found to be 496.2 nm, and polydispersity index (PI) was found to be 0.680, zeta potential study reveals that formulation was stable.