FORMULATION DEVELOPMENT AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE ORODISPERSIBLE TABLETSAbstract
The objective of the present study was to develop venlafaxine hydrochloride orodispersible tablet by using conventional techniques which are simple and cost effective such as use of superdisintegrant technology. In this, sodium starch glycollate and Crosscarmellose sodium were used in the rapid disintegration of the tablets. In this various trials were conducted for the selection of optimum concentration of superdisintegrant. The optimized formula aids in the stabilization of final product. The blend and compressed tablets were evaluated for physical characteristics like bulk density, tapped density, angle of repose, hardness, friability, disintegration time, wetting time, water absorption ratio, In-vitro dispersion time and chemical characteristics like In-vitro dissolution, content uniformity and assay. The stability study was conducted for the optimized batch. This design of dosage form will open a new era for rapid disintegration tablets.
B.Senthilnathan* and Anusha Rupenagunta
School of Pharmaceutical Sciences, Department of Pharmaceutics, Vels University, Pallavaram, Chennai, Tamil Nadu, India
20 December, 2010
17 February, 2011
05 March, 2011
01 April, 2011