FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF BUCOADHESIVE TABLET OF CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN COMBINED DOSAGE FORM

Delivery of the desired drug as bioadhesive drug delivery systems has been subject of interest since 1980s. The various advantages associated with these systems made the buccal drug delivery as a novel route of drug administration. Buccal region offers an attractive route for the administration of systemic drug delivery. The objective of the study was to develop bucoadhesive buccal tablets of Chlorpheniramine Maleate and Phenylephrine Hydrochloride in combined dosage form. Buccal tablets were prepared by Wet granulation method using the Carbopol 934P, Hydroxy propyl methyl cellulose (HPMC), and sodium CMC as bioadhesive polymer. The tablets were evaluated for the precompression parameters and post compression parameter like bioadhesive strength, In vitro retention time, and In vitro drug release study and microbial analysis. The thickness and weight of the tablets, respectively, ranges from 3.82 ± 0.01 and 3.92 ± 0.02 and the weight of tablets ranges from 201-202mg.The Formulation containing sodium CMC and HPMC shows acceptable bioadhesive strength but erode respectively, with in 6 to 8 hours. The tablet formulation containing carbopol and Sodium CMC shows low bioadhesive strength, for release of drug and sufficient In vitro retention time. The optimized formulation obeys the zero order release kinetics.