FORMULATION DEVELOPMENT AND IN VITRO – IN VIVO CHARACTERIZATION OF ORAL FAST DISINTEGRATING FILMS OF A DRUG MEANT FOR CHRONIC DISEASE
AbstractThe objective of the work was to design oral FDFs of a drug meant for management of chronic disease like type-2 diabetes mellitus which affects mostly elderly population. Glimepiride was the drug of choice because of its low dose. Since in vitro dissolution rate is the rate limiting step in drug absorption for class II drugs, in the present work,it was also proposed to make a complex of the drug with hydroxypropyl betacyclodextrin (HPBCD) to improve the physicochemical-pharmacokinetic characters of the drug. Various batches of FDFs were developed by the solvent casting method using water soluble polymers HPMC-E5 and Maltodextrin as film formers; Glycerol and PEG-600 as plasticizers; Sodium starch glycollate
Article Information
32
287-295
867KB
1827
English
IJPSR
P. Vijayalakshmi*, E. Surender , B. Pragna , Md. Zia Askary , Lohidasu Borubhadra , A.J. Balamurugan and Hemant Joshi
Department of Pharmaceutics, Vijaya College of Pharmacy, Hyderabad, Andhra Pradesh, India
pvldss@yahoo.com
02 September, 2012
05 November, 2012
27 December, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).287-95
01 January, 2013
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