FORMULATION DEVELOPMENT OF AMOXICILLIN MICROSPHERE USING NOVEL NATURAL POLYMER
AbstractAmoxicillin is an antibiotic beneficial for the treatment of some bacterial infections. When orally administered it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Amoxicillin and produce sustained drug delivery. Microspheres can be manufactured from various natural and synthetic materials. In these 14 batches of Amoxicillin, microspheres were prepared using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were evaluated for different parameters i.e % drug yield, % drug entrapment, shape, surface morphology, particles size, polydispersity index, zeta potential and in-vitro drug release for 48 hours in phosphate buffer 7.4. The best batch performed stability studies for 6 months. The research concluded that Amoxicillin microspheres could be an alternative for conventional dosage form and other phytochemical in herbs. The optimized formulation was found with significant loading efficiency.
Article Information
15
2573-2578
834 KB
571
English
IJPSR
Singh Priyanka *, Khare Ankita and S. Nayak
Department of Pharmaceutics, Bansal College of pharmacy, Bhopal, Madhya Pradesh, India.
psbansalpharmacy@gmail.com
01 April 2025
17 April 2025
25 April 2025
10.13040/IJPSR.0975-8232.16(9).2573-78
01 September 2025
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