FORMULATION OF CLINDAMYCIN NANO-EMULSION
AbstractNano-emulsions consist of fine oil-in-water or water-in-oil dispersions, having droplets covering the size range of 10 – 600 nm. The aim of this study is to formulate nano-emulsion of Clindamycin by using Emulsion Phase Inversion method and olive oil as the oil phase. Pseudo ternary phase diagram was first developed by using distilled water, olive oil and mixture of surfactants (Tween®80 and Span®20) at a ratio of 1:1. Then, appearance test and microscopic examination were done for all the pre-formulation. Three potential pre-formulation were then selected and incorporated with the Clindamycin Phosphate and Methyl Paraben. The mean droplet size and stability studies were done for these three formulations. Clindamycin Nano-emulsions were not obtained using the Emulsion Phase Inversion (EPI) method in this study, whereby the mean droplet sizes were in micro-range. However, out of all the three formulations which undergone extensive studies which include the heating-cooling cycle, whereby the formulation F8 and F17 were found to be physically stable. Significant differences were identified on the pH value and viscosity measurement for all the three formulations which undergone the heating-cooling cycle; except for the pH in F17. Furthermore, the formulation F8 had the smallest droplet size of 0.92 µm. Future research on this topic is needed to reduce the droplet size of the formulation.
Article Information
4
1845-54
518
2127
English
Ijpsr
K. Jiyauddin *, A. Fadli , J. C. Wei , A. Jawad , A. D. Samer , M. Kaleemullah, S. Budiasih, S. Rasha , M. R. Rasny , Y. K. Sung , A. H. Junainah , H. Todo and Y. Eddy
School of Pharmacy, Management & Science University, 40100 Shah Alam, Selangor Darul Ehsan, Malaysia
jiyauddin_khan@msu.edu.my
08 September, 2014
22 November, 2014
06 January, 2015
10.13040/IJPSR.0975-8232.6(5).1845-54
01 May, 2015