FORSKOLIN AND METABOLIC HEALTH: A REVIEW OF COLEUS FORSKOHLII’S ROLE IN WEIGHT MANAGEMENT AND BEYOND

Coleus forskohlii (syn. Plectranthus barbatus), a medicinal plant from the Lamiaceae family, has been traditionally used in Ayurvedic medicine. Its primary bioactive compound, forskolin, a labdane diterpene, is known for its metabolic and weight management effects. Forskolin activates adenylate cyclase, increasing cyclic AMP (cAMP) levels, which regulate lipid metabolism, thermogenesis, and energy expenditure. This review compiles information from databases such as Google Scholar, PubMed, Science Direct, and Research Gate. Preclinical studies suggest that C. forskohlii extract (CFE) reduces body weight, adiposity, and dyslipidemia in obese models, while clinical trials indicate its potential to prevent weight gain and improve body composition. Beyond weight management, forskolin shows promise in glaucoma, and metabolic disorders. Safety studies confirm CFE has low toxicity, with no significant adverse effects observed. Forskolin also influences hormone regulation and smooth muscle relaxation, contributing to its therapeutic applications. To establish the long-term efficacy and safety of forskolin, large scale placebo-controlled trials are required. This review highlights the pharmacological applications, mechanisms, and safety of C. forskohlii, emphasizing its potential as a natural therapeutic agent for metabolic health and obesity management.