GASTROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF TRICHOSANTHES DIOICA FRUIT ON EXPERIMENTAL GASTRIC ULCER IN RATS

Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to diminish millions of people suffering from ulcer in the country. This will not only provide them relief but will be safe enough from side effect as observed in allopathic medicines. So present study was to investigate gastro protective effect of selected Indian medicinal plant Trichosanthes dioica belonging to family: Cucurbitaceae. 50% ethanolic extract of Trichosanthes dioica fruit extract (TDE) was used for gastro protective effects on experimental models in rats. The entire drug solutions were prepared in 1% CMC solution and administered twice daily for five days or 10 days for prevention using three distinct animal models Model 1: Pylorus ligation + aspirin induced gastric ulcer model, Model 2: Acetic acid induced gastric ulcer, Model 3: Ethanol-hydrochloric acid induced gastric ulcer. Estimation of other biochemical parameter like total acidity Peptic activity, muco-substances, total hexoses, hexosamine, fucose, sialic acid and Protein also.