GLIMPSE OF PHARMACEUTICAL COATING PROCESSESAbstract
Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improvement from non-aqueous F-C to aqueous film-coating (AF-C). Non-aqueous film-coating processes (F-CP) make use of a volatile organic solvent (VOS) while AF-C processes uses aqueous solvent (AS), as a solvent system for coating formulations (C-F). VOS is preferred over AS in F-CP, and momentum for using AS has been accelerating from past few decades. Issues from VOS’s use upraised relating to safety; worker hygiene & safety; toxicity; environmental pollution; etc. These upraised issues intensified, thus, nowadays, AF-C processes are replacing VOS-based F-CP. Later on, finding the novelty of coating and CoPr thru coating of particulates became another dimension of expansion. This involves modification and/or alteration in innate properties of particulates, chemically and/or physically, thru coating, is for find their worthy attributes and functionalities. This dimensional expansion exploits the applicability of the dry-coating process (D-CP) and wet-coating process (W-CP). D-CP comprises novel and specialized CoPr based on novel technologies while W-CP comprises conventional and novel CoPr. Some state-of-art CoPr are AF-C process, hot-melt coating (H-MC) process, electrical-electrostatic deposition process, gas-/vapor-phase process, aerosolized CoPr, photo-curable CoPr, Resonant acoustic CoPr, thermal and mechanical process, thermo-mechanical CoPr, fluidized-bed processes, Supercell® CoPr, etc. CoPr and its dimensional expansion briefed for updating professionals.
Mahammed Athar Alli Saikh
Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India.
21 February 2022
28 April 2022
04 May 2022
01 November 2022