GLYCINE AND GOLD NANOPARTICLES FOR THE ELECTROCHEMICAL DETERMINATION OF AN ANTI-PARKINSON’S DRUG IN A TERTIARY MIXTUREAbstract
A sensitive sensor for the electrochemical determination of anti-Parkinson’s disease drug; entacapone (EN) was constructed using carbon paste electrode modified via electro-polymerization of glycine (GL) incorporate gold nanoparticles (GNP) and sodium dodecyl sulphate (SDS). Different voltammetric techniques, electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) techniques were used to characterize the properties of the modified electrode. The linear response was obtained for EN in the ranges of 4.1×10−7 to 0.5×10−3 mol L−1 with correlation coefficient 0.9990. The lower limit of detection was found to be 2.82 x10-9 mol L−1. The effectiveness of this sensor was established for the determination of EN in real samples. Also the simultaneous determination of EN with Levodopa LD and Carbidopa CD that are present in Stalevo tablets gives a good separated peak potential. Very low detection limit, simplicity of preparation and surface restoration, make the proposed modified electrode very useful for precise determination of EN either alone or in the tertiary mixture.
S. M. Azab*, A. M. Fekry and M. A. Mohamed
Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research [NODCAR], Giza, Egypt.
28 March, 2017
19 May, 2017
27 May, 2017
01 November, 2017