HAEMATOLOGICAL AND BIOCHEMICAL CHANGES IN PRE AND POST TREATMENT OF BUCCAL MUCOSA CARCINOMA PATIENTS

Oral squamous cell carcinoma is one of the lead­ing causes of mortality in India.  The various haematological and biochemical changes including liver enzymes imbalance occur in cancer treatment. The careful monitoring of serum biochemical and haematological changes had very important role in prognosis of disease. Therefore, the present study aimed to study haematological and biochemical changes in pre and post treatment of buccal mucosa carcinoma patients. In study, totally 198 buccal mucosa carcinoma subjected were included from both genders. We observed the Haematological parameters (level of completer haemogram, differential leucocytes count), biochemical and liver function parameters in pre and post treatment of subjects. The serum biochemical and haematological levels were lower in post treatment groups than before treatment of subjects, whereas glucose level did not show significant changes. Hence, the subjects did not affected by diabetics. Most of subjects had anaemic, treatment severely affected bone marrow. However, these changes were exists statistically significant by paired samples t-test at p˂0.001. The biochemical and haematological changes were additional risk for subjects. Thus, these changes will help the prognosis and proper monitoring of the cancer subjects