HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAYRATIA PEDATA VAR. GLABRA AGAINST PARACETAMOL-INDUCED LIVER DAMAGE IN ALBINO RATS

The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six groups viz., Group I served as control, Group II served as a toxic group, Group III received Silymarin and Group IV, V and VI received plant extracts at the rate of 100, 200 and 400 mg/kg. After group segregation, on 15^th day, Paracetamol was administered to groups II, III, IV, V, and VI. The results indicate that compared with Group II the Group I are significant at p<0.05. However, Group III, IV, V, VI are significant at p<0.05 when compared with Group II. Pretreatment with ethanolic extract-treated groups significantly prevented the physical, biochemical, histological, and functional changes induced by Paracetamol in the liver. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities like SGOT, SGPT, ALP, and B, whereas the total serum protein was significantly increased as compared with the induced group, which was supported by histopathological studies of the liver. The results concluded that the ethanol extract of the study plant showed significant hepatoprotective activity compared with standard drug and a hepatotoxin. Based on the above results, it is concluded that the C. pedata var. glabra has potential effectiveness in treating liver damage in a dose-dependent manner.