HEPATOPROTECTIVE ACTIVITY OF SACHHARUM OFFICINARUM AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
AbstractThe hepatoprotective activity of juice of Saccharum officinarum was investigated against paracetamol (acetaminophen) induced liver damage in rats. Paracetamol (PCM) is analgesic, antipyretics drugs available as an over the counter (OTC) medication which cause hepatotoxicity as higher doses. Paracetamol at 3gm/kg induced liver damage in rats manifested by statically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), total and direct billirubin. The antioxidant parameter malondialdehyde (MDA) level was increase and reduced glutathione (GHS), total protein (TP) level were decrease. The physical parameter of liver weight and volume also increase. Histopatholgical and in vitro (% of cell viability) studies of the experimental animals were also done. The results indicate that the juice of Saccharum officinarum protects against PCM-induced hepatotoxicity presumably via antioxidant action.
Article Information
12
102-108
484 kB
1215
English
IJPSR
B. A. Patel*, J. D. Patel and B. P. Raval
K. J. College of Pharmacy, Vadasma, Mehsana, Gujarat, India
bhavikpatel1984@yahoo.co.in
26 January, 2010
13 March, 2010
22 March, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(4).102-08
01 April, 2010
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