HIGHLY BIOACTIVE ULTRA SMALL VANCOMYCIN DOPED SILVER NANOPARTICLES GROWN BY SOL-GEL METHOD

Highly bioactive ultra-small vancomycin doped silver nanoparticles were synthesized by the sol-gel method. The samples were characterized by UV, FR-IR, XRD, Photoluminescence, and TEM analysis. Continuous stirring helped in preparing ultra-small drug conjugate silver nanoparticles. Observation of weak (broadened peak) in XRD diffractograms indicates the formation of very small size drug conjugate sliver nanoparticles. Doping of Vancomycin drug improves the antibacterial activities of silver nanoparticles in the serial dilution method and results in strong yellow, green, and blue luminescence peaks. Antibacterial assay showed that sliver nanoparticles conjugation with vancomycin drug enhanced the antibacterial activity against a variety of gram-positive bacteria like E. coli, S. aureus, and Enterococcus faecalis. These findings suggest that modifying clinically approved drugs using nanotechnology is a feasible approach in our work for effective antibacterial molecules. The results of this study revealed that the potential therapeutic applications of silver nanoparticles in combination with vancomycin antibiotic had been increased drastically. Nanosilver with antibiotic is a promising candidate for the development of future antibacterial therapies because of its wide spectrum of activity.