HYPOGLYCEMIC AND HEPATOPROTECTIVE EFFECT OF MERREMIA VITIFOLIA IN MICE
AbstractTraditionally, Merremia vitifolia meets multipurpose medicinal uses in tribal areas. Therefore, the study worked on hypoglycemic and hepatoprotective effects on animal models to meet the research gap on this plant. Methanolic stem extract at 200 mg/kg and 400mg/kg were administrated orally to determine the effects on blood glucose and hepatic enzymes. The highest dose showed a significant (p < 0.01) reduction in blood glucose. Maximum glucose level reduction (52.1%) was observed at 400 mg/kg extract with 3.5±0.6 mmol/L after 3 h, while reference glibenclamide (10mg/kg) reduced 25.2% with 4.4±0.8 mmol/L. The plasma levels of alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase of CCl4 intoxicated mice were 108.8, 43.4, and 268.8 IU/L at 400 mg/kg, where the values for reference silymarin (100 mg/kg) were 103.4, 54.3, and 237.7 IU/L, respectively. The reduction of alkaline phosphate and alanine aminotransferase levels were moderately (p<0.01) and minimally (p<0.05) significant at concentration 400 mg/kg, respectively. Therefore, the study explored the plant’s potential hypoglycemic and hepatoprotective effects, where the hypoglycemic effect was strongly significant.
Article Information
15
2314-2319
514 KB
241
English
IJPSR
Kawser Ahmed, Mohammad Hasanuzzaman and Prodip Kumar Baral *
Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
pkb.phar@nstu.edu.bd
12 February 2024
25 June 2024
06 July 2024
10.13040/IJPSR.0975-8232.15(8).2314-19
01 August 2024
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