IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST EXFOLIATIVE TOXIN A ASSOCIATED WITH STAPHYLOCOCCUS AUREUS INFECTION – A MOLECULAR DOCKING APPROACH

Staphylococcus aureus is a frequent colonizer of the human body as well as a serious human pathogen. It can cope with stress factors and acquire resistance to antibiotics, thus rendering treatment difficult. Discovering new treatments for this disease is urgently required, especially in view of the emergence of multiple drug resistant organisms and to reduce the total duration of current treatments. Exfoliative toxin A (ETA), produced by Staphylococcus aureus causes scalded skin syndrome which is characterized by the separation of layers of skin. It affects newborns and adults primarily. Hence, therapies for Staphylococcal scalded skin syndrome (SSSS) are critically needed. Seeking a more effective compound for the treatment has been one of the great interests. In the present study, compounds from different plant extracts are permissible to interact with ETA using Schrodinger. The best effective compound gymnemic triacetate was selected from the list of different compounds based on its docking score and binding energy. The result showed that the herbal compound gymnemic triacetate possesses anti-bacterial activity by blocking exfoliative toxin A.