IMPORTANCE OF DRUG EXCIPIENT COMPATIBILITY STUDIES BY USING OR UTILIZING OR EMPLOYING VARIOUS ANALYTICAL TECHNIQUES – AN OVERVIEW
AbstractThe interaction/incompatibility of drug excipients is a major concern in formulation generation. Compatibility tests for drug excipients constitute an important step of the production of all dosage forms in the preparation stage. The possible physical and chemical interactions of drugs and excipients can influence chemical, physical, therapeutic properties and the dosage form’s stability. The current review involves a fundamental mode of drug degradation, a process of physical, chemical and biopharmaceutical interaction between drugs and excipients. The study of incompatibility is explored in various thermal and nonthermal methods. Once the interaction form is identified, further steps can be taken to enhance drug and dose stability. Current and potential reviews of case studies relating to drug and excipient interactions and their unavoidable incompatibilities have also been studied to deepen greater information about such drug solution scenarios. From the review, we conclude that the subsequent use of the thermal and nonthermal methods provides information for the drug-excipient interaction, which can aid the production of safe dosage forms by selecting an excipient.
Article Information
11
3473-3485
644 KB
1335
English
IJPSR
R. Rajesh *, Velimidi Navya and Selva K. Kumar
Department of Pharmaceutical Analysis, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Hessarghatta Main Road, Bengaluru, Karnataka, India.
rajeshr@acharya.ac.in
28 September 2021
20 July 2022
10 August 2022
10.13040/IJPSR.0975-8232.13(9).3473-85
01 September 2022
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