IN-VITRO ANTHELMINTIC ACTIVITY OF ENICOSTEMMA LITTORALE BLUMEAbstract
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Despite this prevalence of parasitic infections, the research on antihelmentic drug is poor. As per WHO, only few drugs are frequently used in the treatment of helminthes in human beings. Antihelmentic from the natural sources may play a key role in the treatment of these parasitic infections. In view of this petroleum ether (60-80º C) and ethanolic extracts of aerial parts of Enicostemma littorale Blume were evaluated separately for the activity on adult Indian earthworms, Pheretima posthuma, using albendazole as reference standards. Five concentrations (2.5, 5, 10, 25 & 50 mg/ml) of each extracts were studied in activity, which involved the determination of time of paralysis and time of death of the worm. The results indicated that the ethanolic extract was more potent than the petroleum ether extract.
Shilpi Mishra*, Ashish Mishra, Padmini Shukla and Prabodh Shukla
Advance Institute of Biotech & Paramedical Sciences, Kanpur, Uttar Pradesh, India
24 January, 2010
14 March, 2011
14 April, 2011
01 May, 2011