IN-VITRO ANTI-INFLAMMATORY STUDIES IN CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)Abstract
The present study evaluates the anti-inflammatory potential of the methanol and chloroform extracts of Cleome viscosa and C. burmanni by in-vitro methods.The anti-inflammatory property of the extracts was assessed using albumin denaturation assay, proteinase inhibitory activityand hyaluronidase inhibition assay and the results compared against reference drugs such as Aspirin and Indomethacin. The present findings exhibited a concentration dependent inhibition of albumin denaturation and hyaluronidase enzyme by the extracts of both plants. Proteinase activity was also significantly inhibited by both plant extracts. The methanol extract was more effective than chloroform extract and was comparable to the standards.From the present study, it can be concluded that the extracts of C. viscosa and C. burmanni possessed marked in- vitro anti-inflammatory activity and the effect could be due to the presence of various phytochemicals present in the plants.
Lakshmi S. Pillai* and Bindu R. Nair
Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram – 695 581. Kerala, India.
24 April, 2014
23 June, 2014
19 July, 2014
01 November, 2014