IN-VITRO STUDY OF AMLODIPINE AND NIFEDIPINE DRUGS OF PULSATILE DRUG DELIVERY SYSTEM

To develop pulsatile microspheres of amlodipine and nifedipine drug release, a blend of polymer and solvent were used with pulsatile principles of drug delivery system to modified drug release pattern on and to release the drug at a particular time on the basis of lag time. In this study, we assessed the in vitro drug release pattern of the formulation prepared from different polymers ratio with the drugs of calcium channel blockers i.e. Amlodipine and Nifedipine. Different formulations of Amlodipine and Nifedipine were prepared using polymers Eudragit RS100, Eudragit S100, Carbopol 971P and polyvinyl alcohol. Optimum formulations were selected from both the drugs of pulsatile microsphere formulation such as formulation N12 from Nifedipine drug and A5 from amlodipine drug by conducting evaluation parameters for microsphere. In vitro studies were carried out for both the formulation and compared to each others. Kinetics drug released kinetics model fitted for both the drugs of optimum formulation for N12 and A5. Formulation N12 showed first order kinetics model and formulation A5 showed zero order kinetics models. Hence both the drugs showed a pulsatile effect, drug released from both the formulation at a particular lag time. The pulsatile dosage form of drug could be useful in chronopharmacotherapy of the treatment of hypertension.