IN-VIVO ANTI-CANCER AND HISTOPATHOLOGY STUDIES OF MORINGA OLEIFERA ON EHRLICH ASCITIC CARCINOMA CELLS

Moringa oleifera is an important food commodity with enormous attention as the ‘natural nutrition of the tropics. Leaves of this plant are traditionally known for or reported to have various biological activities, including hypocholesterolemic agent, antidiabetic, gastric ulcers, antitumor and hypotensive agent. This study was designed to assess the toxicological and histopathological effects of ethanolic leaves extracts of Moringa oleifera in Ehrlich ascites carcinoma (EAC) induced Swiss albino mice. Material and Methods: Toxicity evaluation was carried out according to the OECD guidelines and histopathological assessment of the liver tissues was made using hematoxylin and eosin staining. Results: It indicated that ethanolic extracts did not induce any toxicity up to 1600 mg/kg body weight doses. Examination of ascitic fluid revealed that ethanol extract at 500 mg/kg dose induced degenerative changes and mild signs of apoptosis. Gross pathology of the liver indicated that the extracts did not alter the normal cytoarchitecture of these tissues. Discussion and Conclusion: Findings from this study interpret that ELMO extracts can be used as a complementary therapeutic in the EAC.