IN-VIVO STUDY OF ORODISPERSIBLE TABLET OF PRIMAQUINE
AbstractThe main objective of the study is to evaluate orodispersible tablets of primaquine with different in-vivo parameters. Sharma P et al., (2015), in-vitro study was based on various evaluation parameters of orodispersible tablets of primaquine. From their study results, we have selected formula-6 of orodispersible tablets of primaquine for in-vivo study. Taste masking evaluation was performed on five male Swiss Albino rats (200-250 g). The in-vivo bioavailability study of drug were performed on six male white New Zealand rabbits (weighing 2-2.5 kg) and rabbits were randomly divided into two groups of equal size using parallel design. Next step of the study was HPLC analysis, in this study two conditions were followed by us. The conditions were- (a) Sample preparation: Protein precipitation method selected for extraction of drug from plasma because it was very simple and cost effective method for primaquine extraction. (b) Chromatographic conditions: HPLC-DAD-UV (Shimadzu Class-VP Japan) was used for evaluation of chromatographic conditions. With the help of UV and HPLC, marketed preparation (Primacip film coated tablet) and primaquine ODTs (test sample formulation) were compared for pharmacokinetic parameters.
Article Information
49
3506-3510
390
960
English
IJPSR
P. Sharma * and M. Tailang
Department of Pharmaceutics, Shri Ram College of Pharmacy, Morena, Madhya Pradesh, India.
pankajsharma223@gmail.com
25 November, 2017
06 June, 2018
12 June, 2018
10.13040/IJPSR.0975-8232.9(8).3506-10
01 August, 2018